Abstract
Summary
Fractions were prepared by 0 to 33% saturation with ammonium sulfate from the sera of two patients with lupus erythematosus who had circulating anticoagulants. The fractions prolonged the prothrombin and partial thromboplastin times of human but not bovine or canine plasma and inhibited the conversion of human but not bovine prothrombin to thrombin by “product 2.” The findings suggest that the circulating anticoagulants are species specific inhibitors of prothrombin.
Get full access to this article
View all access options for this article.