Effects of in vivo Hyperoxia on Erythrocytes 1. Hemolysis in Mice Exposed to Hyperbaric Oxygenation. ∗

Abstract

Summary

In vivo lytic sensitivity of mouse erythrocytes to hyperbaric oxygenation paralleled their in vitro sensitivity to H₂O₂. In vitro lysis was associated with lipid peroxide formation. The in vivo and in vitro lysis and in vitro lipid peroxide formation were enhanced by vit. E deficiency and reduced by treatment of animals with a tocopherol acetate. It was suggested that hyperoxic hemolysis in vivo was a direct or indirect result of abnormal lipid peroxidation.