Abstract
Summary
The liver, but not the ovary, spleen or diaphragm inactivates homologous rat pituitary gonadotrophin in vitro. Liver tissue damaged by carbon tetrachloride loses this property altogether. Thyroxine prevents such inactivation of gonadotrophin when added to the incubation medium. Liver tissue from thyroidectomized animals causes more potent inactivation of gonadotrophin, which could be prevented by thyroxine both in vitro and in vivo. Liver tissue of intact thyroxine-treated animals does not inactivate gonadotrophin. The possible mechanism of such inactivation is discussed.
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