Abstract
Summary
Acid phosphatase, alkaline phosphatase, adenosinase and β-glucuronidase were determined in the central nervous system and sciatic nerve of rabbits with experimental allergic encephalomyelitis and the enzymatic pattern compared with that of normal rabbits and rabbits with Wallerian degeneration. The only enzymatic change common to both Wallerian degeneration and EAE was an increase of β-glucuronidase, occurring at the respective site of demyelination. A 10-fold increase was observed in the resected sciatic nerve in Wallerian degeneration. In EAE the β-glucuronidase activity gradually increased from the cervical part of the spinal cord down to the sacral section, where the enzyme activity was about 5-fold the normal value.
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