Abstract
Summary
Three groups of normal rabbits were injected with varying amounts of DNA along with a control group which received saline. One year after the DNA injections, the animals were fed a standard feed supplemented with 15% hydrogenated coconut oil for 4 months. All the animals, experimental and control, developed a mild hypercholes-terolemia. At the end of one month of fat feed, all 3 DNA-injected groups had significantly lower serum lipid levels than the controls. However, the continued fat feeding resulted in a quantitative, direct relationship between amount of DNA injected and length of time the rabbits maintained lower serum lipids.
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