Abstract
Summary
Dietary lithocholic acid increased plasma lipid levels, decreased liver fat, increased liver size and induced a marked biliary hyperplasia in chicks fed either a cholesterol-free or supplmented diet. Lithocholic acid increased liver cholesterol levels in chicks fed a cholesterol-free diet and decreased liver cholesterol in chicks fed a cholesterol-supplemented diet. Cholic acid supplementation partially prevented the changes in liver size and plasma liver lipid levels resulting from ingestion of a lithocholic acid-supplemented cholesterol-free diet. In cholesterol-fed chicks, cholic acid afforded almost complete protection against the effects of dietary lithocholic acid.
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