Abstract
Summary
The clotting mechanism in the human, as measured by conventional methods, appears to be unaffected by intravenous estrogen other than by a slight increase in factor V. Following estrogen, intradermal hyaluronidase wheals persist for a longer period than noted with placebos. These changes are confined to the male. Nonspecific serum hyaluronidase inhibitor increases in both sexes following I.V. estrogen. The peak effect is noted at one to two hours, but the changes persist for approximately 8 hours, usually approaching base line levels at 24 hours. These experiments indicated that I.V. estrogens affect the ground substance. We have not attempted clinical evaluation of the use of intravenous estrogens in control of hemorrhage.
Get full access to this article
View all access options for this article.