Abstract
Summary
Significant elevations of plasma free fatty acid (FFA) concentrations have been observed in guinea pigs with experimental allergic encephalomyelitis (EAE). FFA values correlated well with disease index. Increased values were observed prior to marked clinical signs of disease and preceded development of visible lipemia. Those animals with lipemia had the highest FFA concentrations observed. Significant increases in other plasma lipid fractions were noted in guinea pigs fasted from one to ten days but these were smaller in all fractions than increases noted in encephalomyelitic guinea pigs, except for plasma cholesterol. Normal FFA concentration and no visible lipemia were noted in guinea pigs with severe aspermatogenesis. Two possible hypotheses are proposed which might relate these increased lipid fractions to the neurological damage noted in this encephalitis rather than to delayed hypersensitivity.
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