Effect of ∊-Aminocaproic Acid on Deposition of Radioiodinated Fibrinogen and Antibodies to Fibrinogen in Turpentine-Induced Abscesses of the Rat. ∗

Abstract

Summary

An investigation of the effect of orally administered 5% e-aminocaproic acid (EACA) in drinking water on the behavior of intravenously injected I¹³¹-fibrinogen and I¹³¹-antibody to fibrinogen was carried out in both normal rats and rats with abscesses produced by subcutaneous injection of turpentine. Treatment with EACA had no demonstrable effect on either whole-body retention or blood half-life of either I¹³¹-nbrinogen or I¹³¹-antibody in normal rats. The most striking effect of EACA was to decrease greatly the rate of removal of I¹³¹ from the abscess area. Six days after injection of I¹³¹-nbrinogen, 11% of the injected I¹³¹ was still present in single abscesses of EACA treated rats while in non-EACA treated rats the I¹³¹ retained was less than 1% of the injected dose. Similarly, 6 days after injection of I¹³¹-antibody 20% of the injected I¹³¹ was present in abscesses of EACA treated animals and only 4% in abscesses of rats not receiving EACA. In animals with 2 abscesses, the amount of I¹³¹ deposited was greater but not double the amount deposited in single abscesses. This evidence supports the hypothesis that EACA is a potent inhibitor of fibrinolysis in vivo, as well as in vitro.