Abstract
Summary
Embryos of Brachydanio rerio and Rana pipiens when grown in water containing 0.5-2.0 ppm of 1, 3, 5 (10), 16 estra-tetraen-3-ol (a Δ16 steroid) will consistently develop malformations (hyperplasia) in the region of the tail if exposed before the formation of the tail fin occurs.
The author is especially indebted to Dr. Max N. Huffman, Lasdon Foundation Research Institute of Chemotherapy, Colorado Springs, Colo., and to the Research Foundation, Oklahoma State Univ. for financial assistance during these investigations.
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