Abstract
Summary
Oral administration of paromomycin for 5 to 16 weeks, in daily doses of 2 g, resulted in significant (p<0.01) reduction of average total serum cholesterol concentrations by 12 to 24% (average: 18%) in 7 of 10 patients studied. There was no significant change in serum cholesterol levels of the remaining 3 patients. Serum cholesterol concentrations remained low during paromomy-cin administration and returned to control levels after the drug was discontinued. There were no major side-effects. The possible role of the intestinal bacterial flora in the cholesterol lowering effect of paromomycin and other related antibiotics was discussed.
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