Abstract
Summary
Rabbits given volumes of endo-toxin-tolerant donor plasma too small to modify significantly the course of fever produced by a first test dose of endotoxin injected shortly thereafter, display a remarkable degree of tolerance to a larger dose of endotoxin given 24 hours later, compared to identically endotoxin-treated controls. The results are inconsistent with hypotheses invoking any direct effect of the humoral mediator upon the endotoxin.
The technical assistance of Romus Broadway is gratefully acknowledged.
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