Abstract
Summary
The effects of iproniazid on the mammary secretory response to electrical stimulation of the uterine cervix, cold exposure and reserpine injection were tested in estrogen-primed rats, and on lactation in postpartum rats. At the dose levels used, iproniazid significantly depressed the mammary secretory response to electrical stimulation of the uterine cervix but did not significantly modify the mammary secretory response to cold exposure or reserpine administration. Iproniazid significantly reduced the ability of reserpine to stimulate ACTH release while it did not block ACTH release in response to cold exposure, as judged by adrenal and thymus weights. Postpartum lactation was significantly reduced by iproniazid, without producing any significant loss of body weight in the mother rats. These results suggest that iproniazid may inhibit the release of prolactin, ACTH or oxytocin in response to electrical stimulation of the uterine cervix, reserpine injections or suckling.
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