Abstract
Summary
An antiserum against Rons sarcoma virus prepared in the rabbit was found to contain a large quantity of complement-fixing antibodies for RSV and for normal chicken tissue, as well as a high titre of neutralizing antibody against RSV. After absorption of the serum with sheep erythro-cytes and normal chicken tissues, comole-ment-fixing antibody reacting only with RSV remained, as well as a large quantity of the neutralizing antibody. These findings indicate that RSV antibody prepared in the rabbit is capable of fixing complement with RSV. They also support the thesis that the antibody neutralizing RSV is directed against viral and not against normal tissue antigens.
We are grateful to Dr. F. J. Rauscher, under whose supervision and in whose laboratory the neutralization tests were conducted; and to Mr. J. P. Kvedar for preparation of the RSV and chicken tissue antigens.
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