Abstract
Summary
DNA polymerase activity was measured in extracts of liver prepared from rats fed a carcinogenic azo dye. Groups of rats were sacrificed during the period of carcinogenic transformation in the liver, i.e., the first 8 weeks of dye-feeding, and the DNA polymerase activities in the soluble ultracen-trifugal supernatant fraction of liver homo-genates were assayed. A doubling of the rather low enzyme activity of normal rat liver was found at 6 days, the earliest time point, after initiation of dye feeding. Activity continued to increase through the third week of dye feeding to almost 3 times the normal value, then it gradually dropped to values slightly above normal at the end of the eighth week.
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