In vitro Studies Concerning Fluoride Absorption. ∗

Abstract

Summary

In vitro studies were conducted on gastrointestinal segments from albino rats in an attempt to elucidate factors involved in the mechanism of fluoride absorption. The results of these studies suggested that no active transport system is involved since fluoride would not travel against a concentration gradient across the intestinal wall nor was the diffusion rate influenced appreciably by enzyme poisons or temperature changes. In addition, the rate of diffusion varied with the diffusion area as was expected and diffusion was inhibited by physiological concentrations of calcium and magnesium.