Abstract
Summary
Studies were conducted to determine the effect of various different factors upon absorption of fluoride. The results confirm earlier reports concerning rate of fluoride absorption from the gastrointestinal tract with 29.1, 58.1 and 86.4% absorption occurring after periods of 1, 2, and 8 hours, respectively. These data also indicate that anesthesia by ether or sodium nembutal only slightly decreases the rate of fluoride absorption. Starvation prior to ingestion of fluoride increased the absorption of fluoride by 32%. Rate of fluoride absorption in young rats was significantly decreased by calcium and magnesium and significantly increased by iron, sulfate and phosphorus. Molybdenum had no effect in young rats but significantly increased the rate of fluoride absorption in adult animals. Ascorbic acid had only a slight effect upon fluoride absorption in guinea pigs during the first 4 hours after ingestion but increased the absorption after 12 hours.
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