Abstract
Summary and conclusion
Since(1) acetone and glutathione in aqueous solution or added to whole blood did not form any compound not readily reversible under physiologic conditions; (2) the development of ketosis following starvation in human subjects did not result in a lowered blood non-protein sulfhydryl; and, (3) induced metabolic acidosis or alkalosis in rats led to similar results, the decreased blood glutathione in diabetic ketosis must be explained on grounds other than the combination of thiols with ketone bodies, or some simple relation to acid-base balance.
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