Abstract
Summary
Increasing renal tissue concentration gradients have been demonstrated in hydropenic albino and Kangaroo rats for sodium, chloride and urea. No significant gradients could be demonstrated for water, potassium, p-aminohippurate and nitrofurantoin. Non-participation of nitrofurantoin in the solute concentration gradient may limit its effectiveness as a chemotherapeutic agent in pyelonephritis. However, phagocytosis as affected by solute concentration and medullary blood flow as related to diuresis may be of greater importance clinically.
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