Abstract
Summary
The antibody response of the rabbit to administration of various enteric bacteria containing both O antigen and an antigen (CA) common to numerous enteric bacilli was studied with the following results: (1) Administration into the footpad of antigen from E. coli 0111 and 026, S. typhimurium, or S. flexneri, together with Freund's adjuvant, resulted in formation of both CA and O antibodies in high titer. Even a single injection of antigen and complete adjuvant proved to be effective. Complete adjuvant was more effective than incomplete adjuvant. (2) Antigen (supernate) alone injected into the footpad also engendered CA antibodies, although the titers were considerably lower than those obtained after administration with adjuvant. (3) Intravenous injection of these antigens did not result in production of CA antibodies in high titer, but O antibody titers were similar to those achieved with adjuvant. (4) Intravenous administration of S. typhimurium antigen into animals injected previously with Freund's adjuvant into the footpad, failed to elicit CA antibody production. (5) Feeding of viable E. coli 014 led to a moderate CA antibody response. In contrast, feeding of S. sonnei or E. coli 0111 engendered O antibodies but not CA antibodies.
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