Abstract
Summary
Fractionation of rat liver homogenates suggests a dual intracellular localization of monoamine oxidase, with the major portion in the mitochondria and a smaller but significant portion sedimenting with the microsomal fraction. Comparative studies on substrate specificities and Michaelis constants of monoamine oxidase preparations from liver, kidney and heart of rat and guinea pig indicate marked tissue differences in monoamine oxidases. Multiple substrate studies and other data support the view that each tissue contains a single, distinctive major monoamine oxidase.
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