Abstract
Summary
After lethal total body X-irradiation, host mice received bone marrow from normal donors as well as from donors pretreated with host tissue; the results indicated a higher percentage of survivors in the latter case. To aid in interpretation of those results, a xenogeneic chimera (rat→mouse) was assessed for the state of erythrocyte chimerism body weight, hematocrit values and serum antibody titers. The results are in agreement with the idea that the surviving chimeras were immunologically reactive, since both host- and graft-type hemagglutinins were found in their sera 3–4 weeks following treatment. Generally, subnormal hematocrit and body weight values coincided with the emergence of antibody titers.
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