Secretion of 17-Hydroxycorticosteroids in Conscious and Anesthetized Dogs Exposed to Simulated Altitude. ∗

Abstract

Summary

Eighteen experiments were performed on 8 conscious and anesthetized dogs in which the dorsal roots (T₁₁-L₃) had been severed and a glass cannula inserted in the lumbo-adrenal vein. Decompression to 17,000 feet simulated altitude for 2 hours while breathing ambient air (pO₂ 78 mm Hg) caused marked elevations in 17-OHCS secretions in both conscious and anesthetized dogs.