Abstract
Summary
A tracer dose of tritiated testosterone was injected into 6 normal male and 4 normal female subjects and the excretion pattern studied. Ninety per cent or more of the radioactivity appeared in the first 24 hours. Minute but detectable amounts of free testosterone, androsterone and etiochol-anolone were found. Testosterone glucuronide averaged 75 μg and 4 μg respectively in this group of male and female subjects, about 1% of the injected dose, and 0.1% of the dose was present as a pH 1 hydrolyzable fraction. Most of the radioactivity recovered was found in the C19O2 glucuronide and sulfate fractions. Comparison of specific activities suggested that a third of the androsterone and etiocholanolone (totaling about 2.5 mg) was derived from testosterone.
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