Abstract
Summary
Additions of promazine or chlor-promazine in concentrations below 200 μg/ml of media suitable for prolonged storage of dog sperm were without effect on sperm motility. Higher levels of these drugs were spermicidal. Oral administration of chlor-promazine to 8 dogs (4.4 mg/kg of body-weight) every other day or daily for 9 days did not reduce the libido of dogs trained to routine semen collection procedures. Motility of the sperm collected was unaffected, and sperm output was inconsistently higher in the treated group. It is concluded that the in vivo levels of chlorpromazine studied did not alter the normal hypothalamic-pituitary-gonadal relationship.
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