Abstract
Summary
D-aldosterone (1.1 × 10−6 − 1.1 × 10−5M) has been found to be ineffective in preventing the K+ loss from isolated rabbit atrial tissue caused by a high concentration of ouabain (1.7 × 10−6M). This lack of effect in preventing the K+-depleting effect of ouabain was paralleled by a lack of antagonism of ouabain-induced changes in contractile and electrical properties of the atrial muscle. Therefore no evidence was found to support the view that d-aldosterone may competitively antagonize the K+-depleting actions of ouabain on isolated atrial myocardium.
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