Abstract
Summary
Ligated intestinal sections of the digestive tract in chicks were injected in vivo with 8 mg of the coccidiostat, amprolium. Only the duodenum absorbed significant amounts of the drug (91%) in a 1-hour absorption period. A dose-absorption curve for the duodenum revealed a linear response to about 12 mg and a plateau portion associated with fluid accumulation in loops when higher doses of the drug were introduced. Thiamine introduced simultaneously with .315 mg of amprolium (an antimetabolite of thiamine) decreased amprolium absorption significantly when thiamine/amprolium ratios exceeded 4, and amprolium in excess over thiamine decreased thiamine absorption at molar ratios exceeding 7.5.
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