Abstract
Summary
A new isoprecipitin for a rabbit γ-globulin allotype was found during attempts to produce rheumatoid factor-like activity in rabbits by immunization with specific typhoid-antityphoid complexes. This allotypic specificity, originally designated L, was subsequently found to correspond with Type E of Dubiski and Kelus, Type b of Oudin, and and was later reclassified Type A1 of Dray et al. This new antiserum facilitated the immunochemical study of allotypic specificities A1, A2, and A3, which are controlled at the a locus. The sensitized sheep cell agglutination reactions observed with the sera of some of the immunized rabbits appeared to be due to the isoprecipitin for the allotypic specificity A1 reacting with its antigen in the rabbit amboceptor used. The bentonite flocculation reactions observed with the sera of the immunized rabbits may be due to cross-reactions of the rabbit isoprecipitin and human γ-globulin, or to production of a different anti-γ-globulin antibody which reacts primarily with human γ-globulin.
Get full access to this article
View all access options for this article.