Abstract
Summary
Conjugates of monosaccharide and disaccharide haptens to protein have been found to function adequately in the induction and elicitation of delayed hypersensitivity reactions in the guinea pig. The characteristics of these delayed responses paralleled those observed with other ionic and nonpolar haptens. They exhibited the typical carrier specificity associated with the delayed reaction as well as the greater range of hapten cross-reactions than is typical of the customary antihapten antibody interactions. The suggestion is advanced that the absence of the delayed response to purified polysaccharides may be due to their failure to function properly as the carrier of the antigenic determinant involved in delayed reactions.
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