Abstract
Summary
Levorphanol altered the control serum osmolality response to a 5% oral water load in rats. The change at a small dose of levorphanol was consistent with retention of water systemically owing to the antidiuretic effect of levorphanol. At a high dose, another component appeared in the osmolality curve suggesting that inhibition of water absorption from the gastrointestinal tract was occurring. All effects of levorphanol were antagonized by levallorphan.
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