Absence of a Renal Effect from Two Substituted Propanediols

Abstract

Summary

To determine whether the hypotensive effects of meprobamate or mebutamate could be related to a renal action, experiments were performed using the conscious, trained beagle in which urinary electrolytes and renal clearances were measured. Electrolytes were not affected by intravenous doses of 1–90 mg/kg of meprobamate or 10–50 mg/kg, of mebutamate. Clearance of inulin and p-aminohippurate were measured using doses of 30 mg/kg of meprobamate and 20 mg/kg of mebutamate. Neither clearance was affected by meprobamate, and there was only a small reduction in PAH clearance following mebutamate administration. It was concluded that these compounds are without significant renal effects.