Abstract
Summary
Summary and conclusion. Studies have been made of the in vivo incorporation of radioactive glucosamine into the mucopolysaccharides of rabbit liver. After intraperitoneal injection of radioactive glucosamine, acid mucopolysaccharides with high specific activity were isolated from the liver. Radioactively labeled substances with electrophoretic mobility (on paper) and staining characteristics of hyaluronic acid and heparitin sulfate were found. Glucosamine was the only radioactive substance found in the mucopolysaccharide preparations. This radioactivity amounted to only 2.5 to 10.5% of the total bound radioactivity. A system is apparently present which utilizes preformed glucosamine for the synthesis of acid mucopolysaccharides.
Get full access to this article
View all access options for this article.