Abstract
Summary
Injection into rabbits of virusfree soluble antigen preparations obtained from type 5 adenovirus-infected HeLa cells results in production of specific virus neutralizing antibody. The neutralizing antibodies are present in antisera in high titer and are completely type-specific. This is interpreted as evidence that the virus-induced soluble antigens are structurally related to virus protein. Adsorption studies employing purified group-specific (L) antigens derived from types 2, 4, and 5 virus-infected cells and antiserum specific for the type 5 L antigen reveal basic immunological differences in these “common group'antigens: The type 5 L antigen cross-reacted with type 2 and 4 antigens; however, the type 5 antigen, in addition, had an antigenic reactivity which was type-specific.
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