Abstract
Summary
Unilateral renal artery infusions of hypertonic mannitol increase ipsilateral urine flow, but do not change PAH or creatinine clearances in the anesthetized dog, when infused at 300 mg/min for 10 minutes. In the dog with hemorrhagic hypotension, unilateral renal artery infusion of 480 mg/min of hypertonic mannitol produces a 50% increase in renal blood flow ipsilaterally and a 6% increase contralaterally. These effects are seen in the absence of any change in plasma volume or any increase in the hypotensive arterial pressures.
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