Abstract
Summary
A factor reacting with epithelial and mesenchymal nuclei of 54% of skin homografts in dogs, 36% of donor and 19% of host's normal skin could be demonstrated in their respective host's, sensitized lymph supernate by the indirect fluorescent antibody technic. Recipient serum less frequently contained this factor and only against nuclei of donor (14%) and host's normal skin (9%). Pretreatment of skin sections with Dnase failed to alter this reaction. Lymph from homografted dogs exhibited elevation of total protein, albumin and gamma globulin. However, this latter could not be absolutely correlated with the occurrence of antinuclear factor. The precise role of antinuclear factor in homograft rejection remains to be demonstrated.
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