Abstract
Summary
1. In the presence of Ca++ or Mg++, ADP induces agglutination of platelets washed at 4°C. 2. The sulfhydryl inhibitors PCMB, NEM, and MMN inhibit the ability of washed canine platelets to agglutinate with thrombin or ADP in the presence of Ca++. 3. The effectiveness of PCMB in inhibiting platelet agglutinability is dependent upon thrombin concentration used to induce agglutination. The inhibitory action of PCMB is independent of changes in ADP concentration. 4. MMN causes deagglutination of platelets from clumps formed in the presence of 1.0 U/ml thrombin and Ca++, if the MMN is added to the platelet clumps within 30 seconds of agglutination. 5. MMN, at non-inhibitory concentrations (2.0 × 10-5 m or less), induces rapid and intense platelet agglutination in the presence of Ca++.
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