Abstract
Summary and conclusions
Male rats of the Sprague-Dawley strain, which were found to be resistant to the development of dietary cirrhosis, were bred with random females of the same strain. In 3 generations of rats so bred there appeared to be a sharp increase in the proportion of resistant males. However, when resistant males derived from resistant fathers and grandfathers were crossed with their daughters or sisters there was a sharp decline in the proportion of resistant male offspring. It is suggested that resistance to dietary cirrhosis in the rat may be attributable to an inherited trait or traits, and that other factors, either environmental or genetic, may exert a modifying influence.
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