Abstract
Summary
Incorporation of radioactivity into serum free and ester cholesterol of 4 dogs was studied before and during administration of methyltestosterone 200 mg/day, 6 days/week. Methyltestosterone administration caused diminution of serum total and free cholesterol, phospholipids, triglycerides and C/P ratios. Degree of esterification of cholesterol remained essentially unchanged. Both high density (α) and lower density (β) lipoprotein concentrations decreased. The specific radioactivity of free cholesterol was depressed by methyltestosterone in all animals while ester cholesterol specific activity was unchanged in 2, increased in one and diminished in the other. The average total radioactivity present in ester cholesterol during methyltestosterone administration was increased in relation to that in free cholesterol and equalled it as early as 1 1/2 hours after C14-acetate injection.
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