Abstract
Summary
A technique was developed by means of which determinations of cardiac output, total peripheral resistance, mean circulation time, total blood volume and central blood volume can be repeated in a given rat. The above hemodynamic parameters were determined before and after ganglionic blockade with pentolinium in both male and female rats. Blood pressure fell approximately 50% after blockade; the responsibility for the reduction being equally divided between fall in cardiac output and reduced total peripheral resistance. Total blood volume was not significantly changed and central blood volume decreased slightly. Mean circulation time was increased after blockade. There was no apparent difference between male and female rats in their response to blockade.
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