Abstract
Summary
Thalidomide fed in total doses of 70, 140, 500 or 1700 mg per hen (daily dose of 2.5 mg, 5.0, 25 and 85 mg/kg/day) increased the number of infertile eggs, fertile eggs which failed to develop and deaths in early and late stages of development. Egg production was not affected. Thalidomide treatment did not lead to an increase in gross malformations of the embryo. The effect of the drug was apparent on embryological development in the hen for as long as 30 days after discontinuing the drug.
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