Effect of Salmonella typhosa Endotoxin on Perfused Dog Spleen. ∗

Abstract

Summary

These results demonstrate that local injection of the endotoxin S. typhosa into the splenic vascular bed of the dog, perfused at a constant flow, results in a progressive increase in calculated vascular resistance. The response of the splenic vasculature to lethal doses of endotoxin, furthermore, is unlike that of the intestine and resembles the response of other organs of the portal circulatory bed, the liver and stomach. Where a persistent venular constriction occurs in the intestine, only a transitory venoconstriction occurs in the spleen.