Abstract
Conclusions
Influenza viruses belonging to immunologic subtypes A, A1, A2, and type B, rapidly and completely destroyed hamster kidney cells cultured in serum-free medium. Intracellular pathologic changes resembled those described for influenza virus infection in other cells. Strains NWS, WS, and FM-1 were serially propagated in cricetine cells beyond theoretical extinction of original inoculum with the production of virus which was infectious for hamster kidney cells as well as chicken embryos and which could be neutralized by immune serum. Hemagglutinin was also produced in cell cultures in sufficient quantities to allow for identification of virus by means of hemagglutination-inhibition tests.
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