Two Murine γ -Globulin Allotypic Specificities Identified by Ascitic Fluid Isoprecipitins and Determined by Allelic Genes

Abstract

Conclusions

1. Two murine γ-globulin allotypic specificities, Asa1 and Asa2 were identified by ascitic fluid isoprecipitins using agar gel immunochemical methods. 2. Only one allotypic specificity, either Asa1 or Asa2, was found in each of 42 inbred strains and substrains of mice. 3. The Asa1 and Asa2 allotypic specificities are inherited by codominant autosomal alleles which are not closely linked with the brown-black locus (linkage group VIII) and the dilute-dense locus (linkage group II). 4. Substrain STR/N has the As_a ¹ allele whereas STR/1N has the As_a ² allele indicating the second known gene difference between these two substrains.