Abstract
Summary
Several chemicals were tested and found to be in vitro inhibitors of chicken serum alkaline phosphatase. Sodium borate inhibited serum phosphatase more in a line bred for high serum level than in a random bred control line. Subsequent studies with this inhibitor on tissues from the two lines showed that intestinal phosphatase activity was depressed significantly more than that in bone, liver, and kidney. These studies indicate that the major portion, if not all, of the increased serum phosphatase of the high line originates in the intestine.
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