Abstract
Summary
Change in the pH of the incubation medium has been shown to have opposite effects upon influx rates of cations and of anions into mitochondrial substance. Alkalinization was associated with increase in influx of Na+ and K+; and conversely, acidification resulted in more rapid influx of Br- and Cl-. Increased sensitivity to pH change was observed in the presence of the buffer ion imidazole. At pH 7 imidazole carries a positive charge and inhibition to influx of Na+ was observed. The inhibition was absent at pH 8.5 with conversion to the uncharged free base.
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