Abstract
Summary
Studies of creatinine and PAHA clearance showed a sufficient reduction of GFR and RPF to explain the antidiuretic action of a large dose (75 mg/kg) of azacyclonol. However, a moderate dose (50 mg/kg) produced antidiuresis in the absence of such changes in creatinine and PAHA clearance. A mild diuretic effect was noted in lower doses (12.5 to 25.0 mg/kg). Azacyclonol in doses from 12.5 to 62.5 mg/kg showed antagonism to the antidiuretic action of vasopressin. It is suggested that this antagonism may be the result of weak ADH-like properties of azacyclonol.
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