Abstract
Summary
Under appropriate conditions rabbit peritoneal macrophages inactivated blood thromboplastin in vitro. In a similar system pulmonary macrophages were inert. The peritoneal macrophages appeared to remove radioactive thromboplastin from the medium, but the data were not as clear-cut. It was not possible to demonstrate increased oxygen uptake by peritoneal macrophages following exposure to thromboplastin since these cells appeared to have maximal oxygen consumption prior to mixing with the clotting reagent. It is concluded that reticuloendothelial cells treat laboratory blood thromboplastin as a foreign body.
Get full access to this article
View all access options for this article.