Abstract
Summary
The effect of GTN on the pulmonary vasculature was tested in animals with an intact circulation, with a mechanical pump substituted for the left ventricle and with the pump by-passing the right ventricle. The results of the experiments indicate that in anesthetized dogs the direct effect of GTN in the pulmonary circuit is to decrease pulmonary vascular resistance. The observed increase in pulmonary artery pressure in intact dogs following the injection of GTN is due to increased pulmonary blood flow.
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