Abstract
Summary
Specificity of the transplantation resistance phenomenon was tested by using only 10 tissue cultured polyoma, SV 40, and F. Sa. No. 3 B hamster tumor cells in sufficiently large numbers of adult hamsters to yield definitive results. Pre-treatment with polyoma virus regularly produced resistance to transplantation of polyoma tumor cells but not of F. Sa. No. 3 B tumor cells; there was evidence of some resistance to SV 40 tumor cells in only 2 of 4 tests. Pre-treatment with SV 40 virus regularly produced resistance to SV 40 tumor cells, although in some tests of a lower order than in the polyoma virus vs polyoma tumor system, but not to F. Sa. No. 3 B cells; there was evidence of some resistance to polyoma tumor cells in only 2 of 4 tests. Pretreatment with adenoviruses, types 12 and 7A, herpesvirus and poliovirus type 1 produced no resistance against any of the 3 tumors tested. Reovirus, type 3, and vesicular stomatitis virus (Indiana strain) propagated in mouse embryo tissue culture, the same cells in which the polyoma virus was grown, produced no resistance against the polyoma tumor cells. The progeny of 10 polyoma hamster tumor cells which formed large tumors in occasional, polyoma-immune adult hamsters, nevertheless, were shown to possess the distinctive, cellular antigen. A sensitive test failed to reveal any cytotoxic antibody in the serum of polyoma-immune hamsters that resisted transplantation of polyoma tumor cells.
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