Abstract
Summary
When pancreozymin-cholecystokinin (Cecekin) was administered to dogs by constant infusion, volume of pancreatic secretion was significantly less after portal than after systemic injection; when given in a single dose, volume remained the same regardless of route of injection. As Cecekin contains secretin, the effect on volume is due, probably, to this hormone and not to pancreozymin. Neither the route (portal versus systemic) nor the mode of injection (single dose versus constant infusion) changed the amylase or trypsin concentration of pancreatic secretion. With the experimental procedures employed, the physiological effect of cholecystokinin seems to be unmodified by intraportal injection.
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